ASSESSMENT OF THE GENERAL CONDITION AND QUALITY OF LIFE OF WOMEN OF POST-REPRODUCTIVE AGE AFTER ASYMPTOMATIC COVID-19 AND 12 MONTHS AFTER MODERATE COVID-19

The aim. To assess the general condition, laboratory parameters, quality of life of women of post-reproductive age after asymptomatic COVID-19 and 12 months after moderate COVID-19. Material and methods. We examined 47 women (45-69 years old), divided into 3 groups: those who did not have COVID-19, not vaccinated (group 1- control;n = 15);women 12months after moderate COVID-19, accompanied by pneumonia (group2;n = 19);women with IgG in theirblood who deny anysymptoms of COVID-19 (group 3;n = 13). Results and discussion. An assessment of the general condition of women in postreproductive age was carried out. In women 12 months after COVID-19 we found a lower level of total bilirubin compared to the group with asymptomatic COVID-19 (p = 0.004). An increase in thrombin time was determined in the groups of patients with symptomatic (p = 0.014) and asymptomatic (p = 0.025) COVID-19 course compared with the control group. Patients with asymptomatic COVID-19 course had a higherlevelofhigh-density lipoprotein cholesterolcompared with thecontrolgroup (p = 0.016) and thegroup 2 (p = 0.006). Compared with the controlgroup, the group 2 had lower scores for general health (p = 0.006), vital activity (p = 0.013), general physical well-being (p = 0.039), physical functioning (p = 0.046);and the group 3 had higher scores in role functioning due to physical condition (p = 0.049). When comparing groups 2 and 3, lower scores in the group of women who recovered from the moderate COVID-19 were found in physical functioning (p = 0.002), pain intensity (p = 0.034), role functioning due to physical condition (p = 0.049), general health (p = 0.003), vital activity (p = 0.018), general physical well-being (p = 0.001). Conclusion. 12months after moderate COVID-19, there is a pronounced deterioration inphysicalandemotionalhealth;and in asymptomaticpatients, betterprotective functions of an organism can be assumed. © 2022 Acta Biomedica Scientifica. All rights reserved.

Superoxide Dismutase Activity in Male and Female Patients of Different Age with Moderate COVID-19.

The study involved 271 patients (132 men and 139 women) with moderate COVID-19. Superoxide dismutase (SOD) activity in erythrocytes was measured spectrophotometrically. In total group of patients (divided into age groups of 18-35, 36-45, 46-60, and 61-90 years), higher SOD activity was found in the 18-35 age group in comparison with the groups 46-60 years (p<0.01) and 61-90 years (p<0.05). Then, the groups were additionally divided by sex. In men, no differences in enzyme activity were found between the age groups. In women of early reproductive age, SOD activity was higher than in groups 36-45, 46-60, and 61-90 years. The sex differences consisted in higher SOD activity in women aged 18-35 years in comparison with men of this age. These data should be taken into account when choosing the tactics of therapy for patients with moderate COVID-19 course.